Preferred Label : Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118;
NCIt synonyms : AR LBD-encoding Plasmid DNA Vaccine MVI-118; pTVG-AR Vaccine; pTVG-AR;
NCIt definition : A cancer vaccine containing pTVG4 plasmid DNA encoding the human androgen receptor
(AR) ligand-binding domain (LBD) (pTVG-AR), with potential immunostimulating and antineoplastic
activities. Upon intradermal administration of AR LBD-encoding plasmid DNA vaccine
MVI-118, the plasmid DNA vaccine expresses AR LBD and may stimulate the host immune
system to generate a cytotoxic T-lymphocyte (CTL) response against AR LBD-expressing
prostate cancer cells. This reduces proliferation of AR-expressing tumor cells. AR,
a tumor-associated antigen (TAA) overexpressed in prostate cancer cells, plays a key
role in the development and progression of prostate cancer; its expression is correlated
with poor prognosis.;
Molecule name : MVI-118;
Origin ID : C121777;
UMLS CUI : C4053487;
Semantic type(s)
- concept_is_in_subset
