Preferred Label : Vofatamab;
Obsolete resource : true;
NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the fibroblast
growth factor receptor type 3 (FGFR3), with potential antineoplastic activity. Upon
intravenous administration, the anti-FGFR3 monoclonal antibody B-701 specifically
binds to and inhibits both wild-type and mutated forms of FGFR3. This may result in
the inhibition of FGFR3 phosphorylation, and thereby preventing its activation and
FGFR3-mediated signal transduction pathways. This results in the inhibition of cell
proliferation and the induction of cell death in FGFR3-expressing tumor cells. FGFR3,
a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays
a key role in tumor cell proliferation.;
NCIt note : See 'Anti-FGFR3 Monoclonal Antibody MFGR1877S(C116863)';
Concept status : Retired_Concept;
CAS number : 1312305-12-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1312305-12-6
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : B-701;
Origin ID : C121649;
UMLS CUI : C4743544;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
