Preferred Label : Polihexanide Solution;
NCIt synonyms : Polyhexamethylenebiguanide Solution; PHMB Solution; Polyhexanide Solution;
NCIt definition : A solution containing the polymer polihexanide, with potential antimicrobial, disinfectant
and wound healing activities. Upon application to a wound, polihexanide strongly binds
to the wound surface and exerts an antiseptic effect through the binding of the positively
charged guanidine groups of polihexanide with the negatively charged phospholipids
of the bacterial cell membrane. This compromises the stability of the bacterial cell
membrane, which results in the leakage of cytoplasmic components and leads to bacterial
cell death. In addition, polihexanide accelerates wound healing by promoting epithelial
cell migration and proliferation.;
Origin ID : C121637;
UMLS CUI : C4053774;
Semantic type(s)
- concept_is_in_subset
