Preferred Label : HCV DNA Vaccine INO-8000;
NCIt definition : A multi-antigen DNA vaccine consisting of plasmids encoding the hepatitis C virus
(HCV) nonstructural proteins 3 (NS3), 4A (NS4A), 4B (NS4B) and 5A (NS5A), with potential
immunomodulating and cancer preventive activities. Administered via intramuscular
injection followed by electroporation, cells transfected with the HCV DNA vaccine
INO-8000 express the encoded HCV proteins, which may elicit a cytotoxic T-lymphocyte
(CTL) response against HCV-infected liver cells expressing the NS3, NS4A, NS4B or
NS5A proteins. This results in the eradication of HCV-infected cells. HCV, a small,
enveloped, single-stranded RNA virus belonging to the Flaviviridae family, is associated
with the development of hepatocellular carcinoma (HCC).;
Molecule name : INO-8000;
Origin ID : C121570;
UMLS CUI : C4053630;
Semantic type(s)
- concept_is_in_subset
