Preferred Label : Netupitant/Palonosetron Hydrochloride;
NCIt synonyms : Netupitant/Palonosetron;
NCIt related terms : Netupitant and palonosetron;
NCIt definition : An orally available combination formulation containing netupitant, a selective neurokinin
1 (NK1) receptor antagonist, and the hydrochloride salt form of palonosetron, a selective
serotonin (5-hydroxytryptamine; 5-HT) receptor subtype 3 (5-HT3) antagonist, with
antiemetic activity. Upon oral administration, palonosetron competitively blocks the
action of 5-HT at 5-HT3 receptors located on vagal afferent nerves in the chemoreceptor
trigger zone (CTZ). This inhibits acute emesis associated with 5-HT secretion and
subsequent 5-HT3 activation. Netupitant competitively binds to and blocks the activity
of the human NK1 receptors in the central nervous system (CNS), thereby inhibiting
NK1 receptor binding of the endogenous tachykinin neuropeptide substance P (SP). This
prevents delayed emesis, which is associated with SP secretion. Altogether, this results
in the prevention of chemotherapy-induced nausea and vomiting (CINV).;
Drug name : Akynzeo;
Codes from synonyms : 351;
Origin ID : C121569;
UMLS CUI : C4028218;
Semantic type(s)
- concept_is_in_subset
