Preferred Label : Lorenzo's Oil;
NCIt synonyms : GTO:GTE Oil;
NCIt definition : An orally-administered oil composed of the monounsaturated fatty acids glyceryl trioleate
(GTO), the triacylglycerol form of oleic acid derived from olive oil, and glyceryl
trierucate (GTE), the triacylglycerol form of erucic acid derived from rapeseed oil,
in a 4:1 ratio, that can be used in the treatment of adrenoleukodystrophy (ALD). Upon
oral administration of Lorenzo's oil, the monounsaturated fatty acids compete with
saturated fatty acids as substrates for enzymes in the elongation of very long-chain
fatty acids (ELOVL) family. This results in the elongation and production of monounsaturated
very long-chain fatty acids (VLCFAs) and reduces the elongation of saturated VLCFAs.
This reduces the plasma levels of saturated VLCFAs and prevents their accumulation
in the brain, thereby preventing demyelination of cerebral nerves and halting the
progression of ALD.;
Origin ID : C121561;
UMLS CUI : C0212874;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
