Preferred Label : Carbon C 14 Roniciclib;
NCIt synonyms : [14C]-roniciclib; [14C]-BAY1000394;
NCIt definition : An orally bioavailable radioconjugate composed of roniciclib, a cyclin dependent kinase
(CDK) inhibitor, radiolabeled with carbon C 14, with potential use for evaluating
the pharmacokinetic profile of roniciclib. Roniciclib selectively binds to and inhibits
the activity of various CDK subtypes, which leads to cell cycle arrest and an inhibition
of tumor cell proliferation. Labeling of roniciclib with the radioactive tracer carbon
C 14 allows for the evaluation of roniciclib's pharmacokinetic profile, including
its absorption, distribution, metabolism, and excretion (ADME). CDKs, serine/threonine
kinases overexpressed in various tumor cell types, play key roles in the regulation
of both cell cycle progression and cellular proliferation.;
Origin ID : C121551;
UMLS CUI : C4055273;
Semantic type(s)
- concept_is_in_subset
