NCIt definition : A glyco-engineered monoclonal antibody directed against the receptor tyrosine kinase
epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon
administration, anti-EGFR monoclonal antibody SYN004 binds to the extracellular domain
of EGFR, which prevents ligand binding and the subsequent activation and dimerization
of the receptor. This inhibits the activation of EGFR-mediated signaling pathways
and inhibits EGFR-dependent tumor cell proliferation. EGFR, a member of the EGFR receptor
tyrosine kinase family, may be overexpressed on the cell surfaces of various tumor
cell types.;