Preferred Label : Attenuated Chimpanzee Adenovirus 5T4 Vaccine;
NCIt synonyms : ChAdOx.5T4 Vaccine; ChAdOx1.5T4 Vaccine;
NCIt definition : A cancer vaccine comprised of a recombinant, attenuated, replication-defective simian
adenovirus vector (ChAdOx1) encoding the human 5T4 fetal oncoprotein (ChAdOx1.5T4),
with potential immuno-activating and antineoplastic activities. Upon administration
of the recombinant attenuated chimpanzee adenovirus 5T4 vaccine, the viral vector
expresses 5T4 and stimulates the host immune system to mount a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing 5T4, which results in tumor cell lysis.
5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types;
its expression is correlated with increased invasiveness.;
Origin ID : C121544;
UMLS CUI : C4055431;
Semantic type(s)
- concept_is_in_subset
