Preferred Label : Dolutegravir;
NCIt synonyms : DTG; 2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-,
(4R,12aS);
NCIt definition : An orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity
against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration,
dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the
transfer of viral genetic material into human chromosomes. This prevents integrase
from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer
step, which is essential for the HIV replication cycle. This prevents HIV-1 replication.;
UNII : DKO1W9H7M1;
InChIKey : RHWKPHLQXYSBKR-BMIGLBTASA-N;
CAS number : 1051375-16-6;
Molecule name : GSK-1349572; GSK 1349572;
Origin ID : C121543;
UMLS CUI : C3253985;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
