Preferred Label : Docetaxel-loaded Nanopharmaceutical CRLX301;
NCIt definition : A nanoparticle-based formulation containing the poorly water-soluble, second-generation
taxane analog docetaxel, with antineoplastic activity. Upon intravenous administration
of the docetaxel-loaded nanopharmaceutical CRLX301, the nanoparticles are able to
accumulate at the tumor site due to the unique characteristics of the tumor's vasculature,
while avoiding normal, healthy tissue. In turn, CRLX301 is taken up by the tumor cell
via macropinocytosis. Subsequently, docetaxel is slowly released into the cytoplasm
where it binds to and stabilizes the beta-subunit of tubulin, thereby stabilizing
microtubules and inhibiting microtubule disassembly. This prevents mitosis and results
in cell death. Compared to the administration of docetaxel alone, this formulation
is able to increase docetaxel's efficacy while avoiding systemic exposure, which minimizes
its toxicity.;
Molecule name : CRLX301;
Origin ID : C121539;
UMLS CUI : C4053653;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
