Preferred Label : Allogeneic CD3- CD19- Selected Natural Killer Cells;
NCIt synonyms : CD3/CD19-depleted Donor NK Cells; Allogeneic CD3-/CD19- NK Cells; Allogeneic CD3-/CD19- Natural Killer Cells; Allogeneic CD3-/CD19- NK Cell Product;
NCIt definition : Human leukocyte antigen (HLA)-haploidentical donor-derived natural killer (NK) cells
that are activated with the cytokine interleukin-15 (IL-15), with immunomodulating
and antineoplastic activities. Upon leukapheresis, the HLA-haploidentical donor peripheral
blood mononuclear cells (PBMCs) are treated to remove T-lymphocytes (CD3 ) and B-lymphocytes
(CD19 ) cells. In turn, NK cells are expanded and activated with IL-15. Upon infusion
of the allogeneic CD3- CD19- selected NK cells, these cells recognize and bind to
tumor cells, and secrete perforins, granzymes, and cytokines, which results in cancer
cell lysis.;
Origin ID : C121445;
UMLS CUI : C4055479;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
