Preferred Label : Imifoplatin;
NCIt synonyms : Phosphaplatin PT-112; Cyclohexanediamine Pyrophosphatoplatinum(II), (1R,2R)-;
NCIt definition : A platinum (Pt)-based agent belonging to the phosphaplatin family comprised of Pt
complexed to a pyrophosphate ligand, with potential antineoplastic activity. Although
the exact mechanisms through which imifoplatin exerts its effect have yet to be fully
elucidated, this agent, upon intravenous administration, binds to certain transmembrane
proteins and activates several genes involved in tumor suppression and apoptosis.
This leads to the activation of various signal transduction pathways, induces S/G2
phase cell cycle, and causes tumor cell apoptosis. In addition, imifoplatin may inhibit
angiogenesis. Unlike conventional Pt-based chemotherapeutics, imifoplatin does not
bind to DNA and is able to overcome drug resistance, which occurs with conventional
Pt-based chemotherapeutics; it also has a more favorable side effect profile and is
more stable in plasma.;
UNII : F5I3T42BXC;
InChIKey : SCMHTXQHAHWVSX-BNTLRKBRSA-L;
CAS number : 1339960-28-9;
Molecule name : PT-112; PT 112;
NCI Metathesaurus CUI : CL474103;
Origin ID : C121375;
UMLS CUI : C5418163;
Semantic type(s)
- concept_is_in_subset
