Preferred Label : PI3Kdelta Inhibitor GS-9901;
NCIt related terms : GS-9901;
NCIt definition : An orally bioavailable, small molecule inhibitor of the delta isoform of phosphoinositide-3
kinase (PI3Kdelta) with potential immunomodulating and antineoplastic activities.
Upon oral administration, PI3Kdelta inhibitor GS-9901 selectively binds to the delta
isoform of PI3K and inhibits its activity. This inhibits the activation of the PI3Kdelta-mediated
signaling pathway and prevents proliferation of PI3Kdelta-overexpressing tumor cells.
Unlike other isoforms of PI3K, PI3Kdelta is expressed primarily in certain tumor cell
types and plays a key role in tumor cell proliferation, motility and survival. The
targeted inhibition of PI3Kdelta is designed to preserve PI3K signaling in normal,
non-neoplastic cells and thus reduces toxicity to normal, healthy cells.;
UNII : U09Q76B8VK;
CAS number : 1640247-87-5;
Molecule name : GS-9901;
Origin ID : C121374;
UMLS CUI : C4053639;
Semantic type(s)
- concept_is_in_subset
- has_target
