Preferred Label : Rebeccamycin;
NCIt synonyms : 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione,1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl);
NCIt related terms : 5H-Indolo[2, 3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12, 13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)-;
NCIt definition : An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium
Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the
DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed
DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called antineoplastic antibiotics.;
UNII : Y96MQM21V9;
CAS number : 93908-02-2;
Molecule name : BRN 4732638;
NSC code : 359079;
ChEBI ID : CHEBI:135511;
Codes from synonyms : NSC0359079; CDR0000045860;
Origin ID : C1213;
UMLS CUI : C0073012;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
