Preferred Label : Nanocell-encapsulated miR-16-based microRNA Mimic;
NCIt definition : A nanoparticle-based formulation composed of a microRNA 16 (miR-16) mimic, a double-stranded,
23 base pair, synthetic RNA molecule, encapsulated in nonliving bacterial minicells
and coated with anti-epidermal growth factor receptor (EGFR) antibodies, with potential
antineoplastic activity. Upon intravenous administration and subsequent transfection,
nanocell-encapsulated miR-16-based microRNA mimic targets EGFR-expressing tumor cells
and facilitates the restoration of expression of the miR-16 family. This leads to
the downregulation of the expression of tumor promoting genes and the inhibition of
tumor cell growth. In addition, restoration of miR-16 expression sensitizes the tumor
cell to certain chemotherapeutic agents. miR-16, a family of microRNAs, is critical
to the regulation of gene expression and appears to have a tumor suppressor function;
its expression is downregulated in various cancer cell types.;
Drug name : TargomiRs;
Origin ID : C121214;
UMLS CUI : C4054425;
Semantic type(s)
- concept_is_in_subset
