Pyrazofurin - CISMeF

Preferred Label : Pyrazofurin;

NCIt synonyms : 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide; Pyrazomycin; Beta-Pyrazomycin; Compound 47599; PRZF; Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl; 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI);

NCIt related terms : Pirazofurin; 47599; Pyrazole, -3-carboxamide, 4-hydroxy-5-.beta.-L-ribofuranosyl-; 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI); .beta.-Pyrazomycin; 4-Hydroxy-3-.beta.-D-ribofuranosylpyrazole-5-carboxamide;

NCIt definition : A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04);

UNII : 4B15044GQZ;

InChIKey : XESARGFCSKSFID-FLLFQEBCSA-N;

CAS number : 30868-30-5;

Molecule name : 47599;

Chemical formula : C9H13N3O6;

NSC code : 143095;

Codes from synonyms : NSC0143095;

Details

Origin ID

C1208;

UMLS CUI

C0072661;

Currated CISMeF NLP mapping
- pyrazofurin [MeSH concept]
- pyrazofurin [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- pyrazofurin [MeSH concept]
- pyrazofurin [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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