Preferred Label : NY-ESO-1-specific TCR Gene-transduced T Lymphocytes TBI-1301;
NCIt synonyms : NY-ESO-1-specific TCR Gene-transduced T Lymphocytes;
NCIt definition : Human peripheral blood T-lymphocytes transduced with a retroviral vector encoding
a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential
antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion
ex vivo, transduction, and introduction into the patient, the NY-ESO-1-specific TCR
gene-transduced T lymphocytes TBI-1301 bind to NY-ESO-1 on tumor cells. This may result
in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells.
NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface
of various tumor cell types.;
Molecule name : TBI-1301;
Origin ID : C120557;
UMLS CUI : C4053586;
Semantic type(s)
- concept_is_in_subset
