Preferred Label : Losatuxizumab Vedotin;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the epidermal growth factor receptor (EGFR), conjugated,
via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin
derivative and a potent microtubule inhibitor, with potential antineoplastic activity.
Upon administration, the monoclonal antibody moiety of losatuxizumab vedotin selectively
targets and binds to EGFR. Upon internalization and proteolytic cleavage, MMAE binds
to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor
cell apoptosis. EGFR, a receptor tyrosine kinase mutated in many tumor cell types,
plays a key role in tumor cell proliferation and tumor vascularization.;
UNII : 17C83BVV62;
CAS number : 1685249-67-5;
Molecule name : ABBV-221;
Origin ID : C120556;
UMLS CUI : C5235377;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
