Preferred Label : MAG-Tn3/AS15 Vaccine;
NCIt synonyms : MAG-Tn3/AS15; MAG-Tn3 Plus AS15 Cancer Vaccine;
NCIt definition : A vaccine containing synthetic multiple antigenic glycopeptide (MAG) composed of tri
Tn glycotope (MAG-Tn3), which is comprised of a dendrimeric, nonimmunogenic lysine
core linked to a tetravalent peptidic CD4 T-cell epitope backbone and each attached
to three Tn antigens (tri-Tn cluster), combined with the immunoadjuvant AS15, with
potential antineoplastic activity. Upon administration of the MAG-Tn3/AS15 vaccine,
MAG-Tn3 induces the production of tumor-specific anti-Tn glycosidic antibodies, which
results in antibody-dependent cell cytotoxicity (ADCC) against Tn-expressing tumor
cells. The Tn carbohydrate antigen, a tumor-associated antigen (TAA), is overexpressed
in a number of tumor cell types. The tri-Tn clusters mimic carbohydrate structures
found on tumor cells. The T-cell epitope stimulates effective T-cell responses. AS15,
a potent adjuvant liposomal formulation that contains CpG 7909, monophosphoryl lipid
(MPL), and QS-21, increases the immune response against the Tn antigens.;
Origin ID : C120555;
UMLS CUI : C4054587;
Semantic type(s)
- concept_is_in_subset
