Preferred Label : Idetrexed;
NCIt synonyms : N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic
Acid; alpha-Folate Receptor-targeting Thymidylate Synthase Inhibitor ONX-0801;
NCIt definition : An alpha-folate receptor (aFR)-mediated inhibitor of thymidylate synthase (TS), with
potential antineoplastic activity. Upon intravenous infusion, idetrexed selectively
targets and binds to aFR-expressing tumor cells. Upon uptake by aFR, this agent binds
to and inhibits TS. This reduces thymine nucleotide synthesis, inhibits both DNA synthesis
and cell division, and leads to tumor cell apoptosis. TS catalyzes the conversion
of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an essential
precursor for DNA synthesis, and plays a key role in cell growth and division. aFR,
a cell-surface receptor glycoprotein, is overexpressed on various tumor cell types,
but is minimally expressed by normal, healthy tissue.;
UNII : Q718FS1C7X;
InChIKey : NVHRBQOZEMFKLD-CUYJMHBOSA-N;
CAS number : 501332-69-0;
Molecule name : ONX 0801; BGC 945; ONX-0801;
Origin ID : C120550;
UMLS CUI : C5418162;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
