NCIt definition : A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of
the carbon at position 2 by the CYP450 enzymes 1A1/1A2. Theoretically, 2-hydroxyestradiol
(2-OHE2) is able to undergo redox cycling, which generates active radicals and induces
DNA damage; however, this estradiol metabolite is very unstable in vivo and is quickly
inactivated by catechol-O-methyltransferase (COMT)-mediated O-methylation and converted
to 2-methoxyestradiol (2-MeE2). 2-MeE2 exerts antineoplastic activities through its
estrogen receptor antagonistic effect and the induction of apoptosis in susceptible
cancer cells.;
UNII : AYU2L67YUU;
InChIKey : DILDHNKDVHLEQB-XSSYPUMDSA-N;
CAS number : 362-05-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 362-05-0
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Currated CISMeF NLP mapping