Preferred Label : 4-Hydroxyestradiol;
NCIt synonyms : 4-Hydroxy-17-Beta-Estradiol; 3,4,17beta-Estriol; 4OHE2; 4-OH-Estradiol; 3,4,17beta-Trihydroxy-1,3,5[10]-Estratriene; 4-OHE2; 4-Hydroxyestradiol-17beta; Estra-1,3,5(10)-Triene-3,14,17beta-Triol;
NCIt definition : A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of
the carbon at position 4 by cytochrome P450 1B1, with potential carcinogenic activity.
The mechanism of action for the tumor promoting activity of 4-hydroxyestradiol (4-OHE2)
is not entirely known but this metabolite undergoes metabolic redox cycling with its
oxidized quinoid form, estradiol 3,4-quinone, and generates reactive oxygen species
(ROS), which induce oxidative DNA damage. 4-OHE2 also activates nuclear factor-kappaB
(NF-kB) and extracellular signal-regulated kinase/mitogen-activated protein kinase
pathways, and induces the expression of certain genes through activation of the estrogen
receptor (ER), which stimulates cellular proliferation in susceptible cells.;
UNII : C3ZO03450E;
InChIKey : QOZFCKXEVSGWGS-ZHIYBZGJSA-N;
CAS number : 5976-61-4;
ChEBI ID : CHEBI:62845;
Origin ID : C120473;
UMLS CUI : C0097109;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
