2-Methoxyestrone

Preferred Label : 2-Methoxyestrone;

NCIt synonyms : 3-Hydroxy-2-Methoxyestra-1,3,5(10)-Trien-17-One; 2-OMeE1; 2-MeE1; 2-MeOE1;

NCIt definition : A metabolite formed during the methylation of 2-hydroxyestrone (2-OHE1) by catechol-O-methyltransferase (COMT), with potential anticarcinogenic and minimal estrogen activities. The mechanism of action for the antitumor activity of 2-methoxyestrone (2-OMeE1) is not known. A high 2-methoxyestrone (2-OMeE1)/2-OHE1 ratio indicates higher methylation efficiency and correlates with a lower cancer risk.;

UNII : SJ5857RRL3;

CAS number : 362-08-3;

ChEBI ID : CHEBI:1189;

Details

Origin ID

C120472;

UMLS CUI

C0046322;

Automatic exact mappings (from CISMeF team)
- 2-methoxyestrone [MeSH concept]
- 2-methoxyestrone [MeSH Supplementary Concept]
- 3-hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one [Substance BNPC]
Semantic type(s)
- Hormone [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-methoxyestrone [MeSH Supplementary Concept]
- 2-methoxyestrone [MeSH concept]
- 3-hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one [Substance BNPC]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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