4-Methoxyestradiol

Preferred Label : 4-Methoxyestradiol;

NCIt synonyms : 4-Methoxyestradiol-17beta; 4-MeE2; Estra-1,3,5(10)-Triene-3,17-Diol, 4-Methoxy-, (17beta)-; 4-Methoxyestradiol-17 Beta; 4-MeOE2;

NCIt definition : An endogenous metabolite formed during the O-methylation of the highly carcinogenic catechol estrogen 4-hydroxyestradiol (4-OHE2) by catechol-O-methyltransferase (COMT), with potential anti-proliferative activity. Even though the exact mechanism of action through which 4-methoxyestradiol (4-MeE2) exerts its effect is not fully elucidated, this chemical appears to have antiproliferative and apoptosis-inducing activities in susceptible tumor cells.;

CAS number : 26788-23-8;

Details

Origin ID

C120469;

UMLS CUI

C0048460;

Automatic exact mappings (from CISMeF team)
- 4-methoxyestradiol [MeSH concept]
Currated CISMeF NLP mapping
- 4-methoxyestradiol [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- 4-methoxyestradiol [MeSH Supplementary Concept]
- 4-methoxyestradiol [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients