" /> 4-Methoxyestradiol - CISMeF





Preferred Label : 4-Methoxyestradiol;

NCIt synonyms : 4-Methoxyestradiol-17beta; 4-MeE2; Estra-1,3,5(10)-Triene-3,17-Diol, 4-Methoxy-, (17beta)-; 4-Methoxyestradiol-17 Beta; 4-MeOE2;

NCIt definition : An endogenous metabolite formed during the O-methylation of the highly carcinogenic catechol estrogen 4-hydroxyestradiol (4-OHE2) by catechol-O-methyltransferase (COMT), with potential anti-proliferative activity. Even though the exact mechanism of action through which 4-methoxyestradiol (4-MeE2) exerts its effect is not fully elucidated, this chemical appears to have antiproliferative and apoptosis-inducing activities in susceptible tumor cells.;

CAS number : 26788-23-8;

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28/05/2025


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