Preferred Label : 16alpha-Hydroxyestrone;
NCIt synonyms : 16alpha-Hydroxy E1; 16 Alpha OHE; Hydroxyestrone-16alpha; 16alpha-OHE; 3,16alpha-Dihydroxyestra-1,3,5(10)-Trien-17-One; 16-alphaOHE1; Estra-1,3,5(10)-Triene-3,16alpha-Diol-17-One; 16alpha-OH Estrone; Estra-1,3,5(10)-Trien-17-One, 3,16-Dihydroxy-, (16alpha)-;
NCIt related terms : 16.ALPHA.-HYDROXYESTRONE;
NCIt definition : A metabolite formed during the catabolism of estrone by the liver through the hydroxylation
of the carbon at position 16 by cytochrome P450 (CYP) family enzymes, including CYP3A4
and 3A5, with potential carcinogenic activity. With increased estrogenic activity
compared to the parent compound, 16alpha-hydroxyestrone (16alpha-OHE1) increases the
expression of ER-responsive genes, which leads to increased proliferation of susceptible
tumor cells. The ratio between the two estrogen metabolites, 2-hydroxyestrone (2-OHE1),
a weak estrogen and metabolite from the 2-hydroxylation pathway, and 16alpha-OHE1,
a metabolite from the 16-hydroxylation pathway, may be used to assess the risk of
certain cancers; a higher ratio of 2-OHE1:16alpha-OHE1 correlates with decreased cancer
risk.;
UNII : JY611949JU;
CAS number : 566-76-7;
ChEBI ID : CHEBI:776;
Origin ID : C120468;
UMLS CUI : C0090532;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
