Preferred Label : Procaspase Activating Compound-1 VO-100;
NCIt synonyms : PAC-1; PAC-1 VO-100;
NCIt definition : An orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic
and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating
complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to
procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for
the proteolytic autoactivation of PC3 into the active form caspase-3. This results
in the selective caspase-3-mediated induction of apoptosis and cell death in cancer
cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a
Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its
expression is minimal in normal healthy cells.;
UNII : 9LIS8N0B2C;
CAS number : 315183-21-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 315183-21-2
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G-SRS /a ;
Molecule name : VO-100;
Origin ID : C120318;
UMLS CUI : C3889731;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
