Preferred Label : Anti-CD157 Monoclonal Antibody MEN1112;
NCIt definition : A humanized, Fc engineered, de-fucosylated monoclonal immunoglobulin G1 (IgG1) antibody
directed against the bone marrow stromal cell antigen 1 (BST1/CD157), with potential
antineoplastic activity. Upon intravenous infusion, anti-CD157 monoclonal antibody
MEN1112 specifically binds to and induces an antibody dependent cell cytotoxic (ADCC)
response against CD157-expressing tumor cells. CD157, also known as ADP-ribosyl cyclase
2, is a glycosyl-phosphatidylinositol (GPI)-anchored transmembrane protein belonging
to the ADP-ribosyl-cyclase family and is overexpressed on certain cancer cell types.
Fc-optimization of MEN1112, which involves the removal of fucose residues from its
Fc domain, allows for enhanced Fc-gamma receptor binding on effector cells, such as
natural killer (NK) cells, and further enhances tumor cell lysis.;
Molecule name : MEN1112;
Origin ID : C120317;
UMLS CUI : C3896815;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
