Preferred Label : Compound Kushen Injection;
NCIt synonyms : Yanshu Injection; CKI;
NCIt definition : A traditional Chinese medicine (TCM) formulation composed of compound Kushen injection
(CKI) containing aqueous extracts from the roots of Kushen (Radix Sophorae Flavescentis)
and Baituling (Rhizoma smilacis Glabrae), with potential antineoplastic and immunomodulating
activities. CKI contains numerous chemicals including alkaloids, such as matrine and
oxymatrine, flavonoids, alkylxanthones, quinones, triterpene glycosides, fatty acids,
and essential oils. Although the exact mechanism(s) of action through which CKI exerts
its effects has yet to be fully elucidated, CKI is able to interfere with the activation
of various signal transduction pathways, such as the Wnt/beta-catenin signaling pathway,
inhibit nuclear factor-kappa B (NF-KB) activation, and block the activity of multiple
receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and vascular
endothelial growth factor receptor (VEGFR). CKI induces apoptosis in and inhibits
proliferation, migration, invasion and adhesion of tumor cells. CKI also modulates
the production of inflammatory mediators.;
Origin ID : C120314;
UMLS CUI : C3890596;
Semantic type(s)
- concept_is_in_subset
