NCIt definition : A humanized monoclonal immunoglobulin G4 (IgG4) antibody targeting the anti-carcinoembryonic
antigen (CEA)-related cell adhesion molecule 1 (CEACAM1; CD66a), with potential immunomodulating
and antineoplastic activities. Upon administration of anti-CEACAM1 monoclonal antibody
CM-24, this agent binds to CEACAM1 on cancer cells and certain immune cells. This
blocks the binding of CEACAM1-expressing cancer cells to CEACAM1-expressing immune
cells and abrogates CEACAM1-mediated immunosuppression. This enhances the activation
of cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells and increases CTL-
and NK-mediated killing of CEACAM1-overexpressing cancer cells. CEACAM1, a member
of the CEA family of proteins that plays a key role in cell migration, cell invasion,
and cell adhesion, is overexpressed by a variety of cancer cell types. Its overexpression
is correlated with both immunosuppression and poor prognosis.;
Semantic type(s)