Preferred Label : Topical Tirbanibulin;
NCIt synonyms : KX2 391 Ointment; KX2-391 Ointment;
NCIt definition : An ointment containing an inhibitor for both Src tyrosine kinase and tubulin polymerization,
with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind
to the ATP-binding site, tirbanibulin binds to the peptide substrate binding site
of Src kinase, upon topical application. This inhibits both downstream signaling and
the proliferation of tumor cells overexpressing Src. Src tyrosine kinase, a non-receptor
tyrosine kinase upregulated in many tumor cell types, plays an important role in tumor
cell proliferation, motility, invasiveness and survival. Tirbanibulin also binds to
tubulin heterodimers and inhibits microtubule polymerization, which disrupts microtubule
formation and mitosis, leading to further inhibition of cell proliferation. In addition,
Tirbanibulin inhibits T-cell migration.;
Origin ID : C120210;
UMLS CUI : C5424489;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
