Preferred Label : Monalizumab;
NCIt synonyms : Immunoglobulin G4-kappa, Anti-(Homo sapiens KLRC1 (Killer Cell Lectin-like Receptor
Subfamily C Member 1, NKG2-a, NKG2a, CD159A, CD94)), Humanized Monoclonal Antibody;
NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody against the human natural
killer (NK) and T-lymphocyte cell checkpoint inhibitor killer cell lectin-like receptor
subfamily C member 1 (NKG2A), with potential antineoplastic activity. Upon administration,
monalizumab binds to NKG2A and prevents the binding of NKG2A to its ligand human leukocyte
antigen-E (HLA-E), which is overexpressed on tumor cells. This blocks the HLA-E-mediated
inhibition of NKG2A-positive infiltrating NK and cytotoxic T-lymphocytes (CTLs) and
induces a NK and CTL-mediated immune response against the cancer cells leading to
their destruction. Human NKG2A, an inhibitory cell surface receptor covalently bound
to CD94, is expressed by NK cells and CTLs. Stimulation of the CD94/NKG2A complex
inhibits the cytotoxic activity of these cells. HLA-E, a nonclassical HLA class Ib
molecule, is often overexpressed on tumor cells and is associated with poor prognosis.;
UNII : 3ZXZ2V0588;
CAS number : 1228763-95-8;
Molecule name : NN8765-3658; IPH-2201; NN-8765;
Origin ID : C120208;
UMLS CUI : C4086595;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
