Preferred Label : NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine;
NCIt synonyms : NY-ESO-1/MART-1 Peptide-pulsed DC Vaccine;
NCIt definition : A cell-based cancer vaccine composed of dendritic cells (DC) pulsed with peptides
derived from the tumor-associated antigens human cancer/testis antigen NY-ESO-1 and
melanoma antigen recognized by T-cells (MART-1/Melan-A), with potential immunostimulatory
and antineoplastic activities. Upon administration, the NY-ESO-1/MART-1-peptide pulsed
DC vaccine may stimulate the immune system to mount an anti-tumor cytotoxic T-lymphocyte
(CTL) response against NY-ESO-1/MART-1-expressing tumor cells, which may result in
tumor cell lysis. NY-ESO-1 is expressed both in normal testes and on the surfaces
of various tumor cells. MART-1 is expressed by melanoma cells.;
Origin ID : C120129;
UMLS CUI : C3898188;
Semantic type(s)
- concept_is_in_subset
