Preferred Label : Branched-chain Amino Acid Supplement;
NCIt synonyms : BCAA Supplement;
NCIt definition : A nutritional supplement containing essential branched-chain amino acids (BCAAs),
including leucine, isoleucine and valine, with potential anti-cachectic, antiangiogenic,
hepatocellular carcinoma (HCC) inhibiting and hepatoprotective activities. Upon oral
administration, BCAAs inhibit the expression of both hypoxia-inducible factor 1-alpha
subunit (HIF-1a) and vascular endothelial growth factor (VEGF), which prevents VEGF-mediated
angiogenesis in HCC cells. In addition, BCAAs inhibit proliferation and induce apoptosis
of HCC cells by both suppressing the expression of insulin-like growth factor (IGF),
and inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway. BCAAs also correct the plasma amino acid imbalance and promote protein
metabolism, including the synthesis of albumin and glycogen. They reduce oxidative
stress by inducing the activation of genes involved in antioxidant defenses, which
prevent the production of reactive oxygen species (ROS). BCAAs also strengthen the
immune system by increasing hepatic lymphocytes and stimulating natural killer (NK)
cell activity. This supplement is able to improve insulin resistance and promote ammonia
detoxification through increased glutamine (Gln) production.;
Origin ID : C120121;
UMLS CUI : C3897130;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Food [UMLS semantic type]
- concept_is_in_subset
