Preferred Label : Gallium Ga 68-RGD;
NCIt synonyms : RGD (68Ga); (68)Ga-RGD;
NCIt definition : A radiopharmaceutical agent comprised of a cyclic arginine-glycine-aspartic acid (Arg-Gly-Asp/RGD)
peptide labeled with gallium Ga 68, with potential alphaVbeta3 integrin (avb3) imaging
activity during positron emission topography (PET). After intravenous administration,
gallium Ga 68-RGD selectively binds to avb3 on the cell membrane via the cyclic RGD
motif. Upon PET imaging, avb3-expressing tumor cells can be visualized and their expression
levels can be quantified. avb3, a member of the integrin receptor family, is overexpressed
on certain tumor cells and tumor endothelial cells while minimally or not expressed
on healthy, normal cells; it plays a key role in angiogenesis, tumor proliferation
and survival.;
Origin ID : C120104;
UMLS CUI : C3899043;
Semantic type(s)
- concept_is_in_subset
