Preferred Label : Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142;
NCIt synonyms : ADXS-PSA; Lm-LLO-PSA;
NCIt definition : A cancer vaccine containing a live-attenuated strain of the Gram-positive bacterium
Listeria monocytogenes (Lm) encoding a fusion protein composed of the tumor-associated
antigen (TAA) human prostate-specific antigen (PSA) fused to a fragment of the immunostimulant
listeriolysin O (LLO) protein, with potential immunostimulatory and antineoplastic
activities. Upon administration of the Lm-LLO-PSA vaccine ADXS31-142, the expressed
LLO-PSA is processed by antigen presenting cells (APCs), presented to the immune system
by both major histocompatibility complex (MHC) I and II molecules, and activates the
immune system to exert both an innate and adaptive immune response involving the recruitment
and activation of T-lymphocytes against PSA-expressing tumor cells as well as the
inhibition of tumor-infiltrating T regulatory cells (T regs) and myeloid-derived suppressor
cells (MDSCs). This eventually results in tumor cell lysis.;
Molecule name : ADXS31-142;
Origin ID : C120103;
UMLS CUI : C3896925;
Semantic type(s)
- concept_is_in_subset
- has_target
