Preferred Label : Fluorine F 18 Ara-G;
NCIt synonyms : 18F-F-Ara-G; 2'-Deoxy-2'-[18F]Fluoro-9-beta-D-arabinofuranosylguanine; [18F]F-ara-G; [18F]F-AraG; (18F)F-Arag; 2-Amino-9-((2R,3S,4R,5R)-3-fluoranyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6-one; [18F]-AraG; F-ARAG F-18;
NCIt definition : A radioconjugate composed of the guanosine analog arabinosyl guanine (Ara-G), a high-affinity
substrate for both cytoplasmic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine
kinase (dGK), labeled with fluorine F 18, that can potentially be used as a tracer
for imaging of activated T-lymphocytes during positron emission tomography (PET).
Upon administration, fluorine F 18 ara-G is taken up by and accumulates in activated
T-lymphocytes with high levels of DCK and dGK. After phosphorylation by DCK and dGK,
the 18F moiety can be visualized by PET imaging. Fluorine F 18 ara-G can potentially
be used as an imaging agent to detect anti-tumor immune responses and to predict the
therapeutic efficacy of immunotherapies. DCK and dGK, both nucleoside salvage pathway
enzymes, are overexpressed in activated T-cells.;
UNII : X96PT3B08G;
InChIKey : UXUZARPLRQRNNX-YXAALHNKSA-N;
CAS number : 1268848-88-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1268848-88-9
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G-SRS /a ;
Drug name : VisAcT;
Origin ID : C120100;
UMLS CUI : C3896947;
Semantic type(s)
- concept_is_in_subset
