Preferred Label : Brilacidin Oral Rinse;
NCIt synonyms : PMX30063 Oral Rinse;
NCIt definition : An oral rinse containing brilacidin, a defensin mimetic, with potential antimicrobial
and anti-mucositic activities. Upon rinsing with the brilacidin oral rinse, brilacidin
imitates defensin as a human host defense protein (HDP), and binds to and disrupts
the bacterial cell membrane. This causes bacterial cell membrane lysis and leakage
of cellular cytoplasmic contents. This inhibits bacterial activity and may prevent
or treat radiation-induced mucositis. Defensins, a family of antimicrobial and cytotoxic
peptides expressed mainly by epithelial cells and neutrophils, play a key role in
the natural human innate immunity against pathogens.;
Origin ID : C120043;
UMLS CUI : C3899908;
Semantic type(s)
- concept_is_in_subset
