Preferred Label : Eicosapentaenoic Acid-enriched Nutritional Supplement;
NCIt synonyms : EPA-enriched Nutritional Supplement;
NCIt definition : A nutritional supplement enriched with eicosapentaenoic acid (EPA), which is an essential,
polyunsaturated, 20-carbon omega-3 fatty acid found in fish oil, with potential anti-inflammatory
and anti-cachectic activities. Upon oral intake of the EPA-enriched nutritional supplement,
EPA is incorporated in cell membrane phospholipids and replaces arachidonic acid.
This affects the production of pro-inflammatory mediators, such as tumor necrosis
factor-alpha (TNF-a), interleukin-1 (IL-1) and IL-6, through the inhibition of nuclear
factor kappa B (NF-kB) activity. This inhibits inflammation and may abrogate the cachexia-mediated
decrease of lean body mass (LBM), which may lead to increased body weight. Pro-inflammatory
mediators, such as TNF-a, interferon-gamma, and certain interleukins, such as IL-6
and IL-1b, play a key role in cachexia.;
Origin ID : C120042;
UMLS CUI : C3899275;
Semantic type(s)
- Food [UMLS semantic type]
- concept_is_in_subset
