Preferred Label : Antigen-targeted Personalized Breast Cancer Vaccine;
NCIt synonyms : IVAC_W_bre1_uID;
NCIt definition : An individualized, therapeutic cancer vaccine (IVAC) composed of liposomes containing
RNA encoding two or three tumor associated antigens (TAAs) that are specifically expressed
in the patient's individual cancer selected from a warehouse (off the shelf) and p53
RNA, with potential immunostimulatory and antineoplastic activities. Upon administration,
the antigen-targeted personalized breast cancer vaccines are translated by antigen
presenting cells (APCs) and the expressed protein is presented via major histocompatibility
complex (MHC) molecules on the surface of the APCs. This leads to an induction of
both cytotoxic T-lymphocyte (CTL) and memory T-cell immune responses against the TAAs.
The RNAs in the vaccine are specifically selected for an individual patient after
RNA profiling of the patient's tumor.;
Origin ID : C120039;
UMLS CUI : C3900022;
Semantic type(s)
- concept_is_in_subset
