Preferred Label : ERK Inhibitor CC-90003;
NCIt definition : An orally available inhibitor of extracellular signal-regulated kinase (ERK), with
potential antineoplastic activity. Upon oral administration, CC-90003 inhibits ERK
activity, and prevents the activation of ERK-mediated signal transduction pathways.
This results in the inhibition of ERK-dependent tumor cell proliferation and survival.
The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a
variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation
and survival.;
Molecule name : CC-90003;
Origin ID : C119747;
UMLS CUI : C3896889;
Semantic type(s)
- concept_is_in_subset
- has_target
