Preferred Label : Globo H-DT Vaccine OBI-833;
NCIt synonyms : Globo H-CRM197 Vaccine;
NCIt related terms : OBI-833;
NCIt definition : A carbohydrate-based vaccine comprised of the Globo H hexasaccharide 1 (Globo H) antigen
conjugated to DT-CRM197, a non-toxic, mutated form of diphtheria toxin (DT), with
potential immunostimulating and antineoplastic activities. Upon administration of
Globo H-DT vaccine OBI-833, the carbohydrate antigen Globo H may stimulate a cytotoxic
T-lymphocyte (CTL) response against Globo H-expressing tumor cells, thereby decreasing
tumor cell proliferation. The hexasaccharide Globo H is a tumor-associated antigen
(TAA) commonly found on a variety of tumor cells. DT-CRM197, also called diphtheria
toxin cross-reacting material 197, is used to increase the immunogenicity of the Globo
H carbohydrate antigen.;
UNII : NC1XBS5AET;
CAS number : 2142641-90-3;
Molecule name : OBI-833;
Origin ID : C119745;
UMLS CUI : C3896801;
Semantic type(s)
- concept_is_in_subset
