Preferred Label : Carbon C 13/Nitrogen N 15-labeled Valine;
NCIt synonyms : ( )-2-Amino-3-Methylbutyric Acid-13C5,15N; L-Valine-13C5,15N; L-2-Amino-3-methylbutanoic Acid-13C5,15N; Carbonomic; C13 N15 Valine;
NCIt definition : A radioconjugate composed of the essential amino acid valine radiolabeled to carbon
C 13 and nitrogen N 15, that can potentially be used as a tracer for protein metabolism
in vivo using mass spectrometry (MS). Upon administration of carbon C 13/nitrogen
N 15-labeled valine, the exogenous valine is taken up by cells and incorporated into
proteins. Upon imaging, protein biomarkers containing radiolabeled valine are secreted
by tumor cells and can be identified by MS. This may aid in cancer diagnosis and prognosis.
Compared to normal cells, tumor cells rapidly take up amino acids to use as protein
building blocks.;
CAS number : 202407-30-5;
Origin ID : C119742;
UMLS CUI : C3899707;
Semantic type(s)
- concept_is_in_subset
