Preferred Label : Yttrium Y 90-DOTA-di-HSG Peptide IMP-288;
NCIt synonyms : 90Y-IMP288; 90-Y-IMP-288;
NCIt definition : A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with
the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
(DOTA) to the beta-emitting radionuclide yttrium 90 (Y-90), with radioimmunotherapeutic
activity. After pre-treating and targeting tumor cells with a bi-specific monoclonal
antibody (BiMoAB) directed against both a tumor-associated antigen (TAA) and the HSG
hapten-peptide, the HSG portion of the administered yttrium Y 90-DOTA-di-HSG peptide
IMP-288 binds to the anti-HSG sequence on the BiMoAB. In turn, Y-90 delivers a cytotoxic
dose of beta radiation to tumor cells expressing the specific TAA.;
Origin ID : C119738;
UMLS CUI : C3896702;
Semantic type(s)
- concept_is_in_subset
