Preferred Label : Mechlorethamine Hydrochloride Gel;
NCIt synonyms : Mechlorethamine HCl Gel;
NCIt definition : A gel formulation composed of the hydrochloride salt form of mechlorethamine, which
is a nitrogen mustard alkylating agent and an analog of sulfur mustard, with antineoplastic
and immunosuppressive activities. Upon topical application, mechlorethamine is metabolized
to an unstable, highly reactive ethyleniminium intermediate that binds to and alkylates
DNA, with a high affinity to the N7 nitrogen of guanine residues. This results in
DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair
and synthesis, cell-cycle arrest, and apoptosis.;
Drug name : Valchlor;
Origin ID : C119736;
UMLS CUI : C3898446;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
