Preferred Label : Carbon C14-labeled Carboplatin;
NCIt synonyms : 14C Carboplatin; Carbon-14-labeled Carboplatin;
NCIt definition : A radioconjugate composed of the platinum compound carboplatin conjugated to the isotope
carbon C 14 (14C-carboplatin), which can potentially be used to predict chemoresistance
to carboplatin using accelerator mass spectrometry (AMS). Upon administration of a
microdose of 14C-carboplatin, the carboplatin moiety covalently binds to DNA and forms
carboplatin-DNA monoadducts. Using AMS, the 14C-carboplatin-DNA monoadducts can be
detected and measured. The levels of microdose-induced carboplatin-DNA monoadducts
can be used to assess the degree of chemoresistance to carboplatin and can predict
cancer response to carboplatin-based chemotherapy. The carboplatin microdose is defined
as 1/100 of the pharmacologically effective concentration of carboplatin. Low levels
of carboplatin monoadduct formation and increased DNA repair, measured by a decrease
in the detection of carboplatin-DNA monoadducts over a given time period, are correlated
with increased resistance to platinum-based chemotherapeutics.;
Origin ID : C119702;
UMLS CUI : C3899706;
Semantic type(s)
- concept_is_in_subset
