Preferred Label : Anti-CD37 MMAE Antibody-drug Conjugate AGS67E;
NCIt synonyms : Anti-CD37 MMAE ADC AGS67E;
NCIt definition : An antibody-drug conjugate (ADC) composed of AGS67C, a human anti-CD37 monoclonal
antibody covalently linked, via reduced cysteines and a protease cleavable linker,
to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule
disrupting agent, with potential antineoplastic activity. Upon administration, the
monoclonal antibody moiety of AGS67E binds to CD37 antigens on tumor B-cells and is
rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage,
MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint
arrest and apoptosis in CD37-expressing tumor cells. CD37, a transmembrane glycoprotein,
is overexpressed in B-cell malignancies.;
Molecule name : AGS67E;
Origin ID : C119700;
UMLS CUI : C3896733;
Currated CISMeF NLP mapping
- AGS67E [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- AGS67E [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
