Pimonidazole - CISMeF

Preferred Label : Pimonidazole;

NCIt synonyms : 1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-;

NCIt definition : A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment.;

UNII : 46JO4D76R2;

InChIKey : WVWOOAYQYLJEFD-UHFFFAOYSA-N;

CAS number : 70132-51-3;

Molecule name : Ro 03-8799; PD 126675;

Chemical formula : C11H18N4O3;

NSC code : 380540;

Codes from synonyms : NSC0380540;

Details

Origin ID

C1196;

UMLS CUI

C0071072;

Currated CISMeF NLP mapping
- pimonidazole [MeSH concept]
- pimonidazole [MeSH Supplementary Concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- pimonidazole [MeSH concept]
- pimonidazole [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Pimonidazole Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Pimonidazole Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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