Preferred Label : Genetically-modified MAGE-A3-expressing MG1 Maraba Virus Vaccine;
NCIt synonyms : MG1MA3; MG1 Maraba/MAGE-A3;
NCIt definition : A vaccine consisting of the attenuated, genetically-modified, oncolytic form of the
Maraba virus, MG1, which has been engineered to express a gene encoding the cancer
testis antigen melanoma antigen family A3 (MAGE-A3), with potential antineoplastic
activity. Upon administration of genetically-modified MAGE-A3-expressing MG1 Maraba
virus vaccine, the attenuated Maraba virus selectively and rapidly replicates in cancer
cells; however, it is unable to replicate in normal, healthy cells. This induces a
selective Maraba virus-mediated cytotoxicity in those cancer cells, and leads to cancer
cell lysis. In addition, the expression of MAGE-A3 further stimulates the host immune
system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing
MAGE-A3. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer
cell types. The attenuated virus is a double mutant strain with single amino acid
substitutions occurring in both G protein (Q242R) and M protein (L123W).;
Origin ID : C118973;
UMLS CUI : C3896648;
Semantic type(s)
- concept_is_in_subset
