NCIt definition : An orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1)
and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential
antineoplastic activity. Upon oral administration, taletrectinib binds to and inhibits
ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and
NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are
overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays
a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements
play a key role in cancer progression.;
UNII : W4141180YD;
InChIKey : HEVHTYMYEMEBPX-HZPDHXFCSA-N;
CAS number : 1505514-27-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1505514-27-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;